Only Watch in Singapore

News • 18 Oct 2019

Only Watch in Singapore


The 8th edition of the biennial auction of unique timepieces sold for the benefit of research on Duchenne Muscular Dystrophy will take place on Saturday 9 November 2019 in Geneva. The full collection of Only Watch timepieces will stop over in Singapore from the 25th to the 26th of October for an open to the public exhibition at Malmaison by The Hour Glass.

When: 25 – 26 October, 11:30 am to 7:00 pm
Where: Malmaison by The Hour Glass, 270 Orchard Road Singapore

The below message is from Luc Pettavino, President – Association Monégasque contre les Myopathies and Founder / Organizer – Only Watch. For more information please visit the Only Watch website.

Luc Pettavino

Over the last 15 years, AMM has been organising “Round Tables in Monaco” on the progress of research for DMD.

And thanks to the Only Watch charity auction, AMM sponsored many laboratories worldwide to explore the most promising therapeutic avenues (stem cell therapy, which consists engrafting fresh cells to rebuild skeletal muscles; gene therapy for targeting a replacement gene coding the missing dystrophin into the whole musculature; and finally antisense strategies to rescue the mutated dystrophin gene product throughout exon-skipping).

Only Watch 2017

Without going into detail, the AMM funding has allowed forefront research laboratories to recruit young scientists, to acquire cutting-edge equipment and to improve significantly their operational resources. AMM has also initiated SYNTHENA in Switzerland and SQY Therapeutics in France, two companies dedicated in drug discovery and preclinical development at the service of the patient’s cause, which are integrated in an international consortium involving academic partners.

Only Watch 2017

At present, we are focussing on several complementary axes of research:Understanding muscle plasticity and physiopathology of the Duchenne muscular dystrophy, investigating cardiac complications to improve life-span of patients, developing new splice-switching compounds to rescue mutated mRNAs and restore dystrophin in all affected tissues of the body and developing new gene vectors that could be re-administered without recourse to immunosuppression protocols.

MB&F L’épée (for Only Watch 2019)

We do our best to keep this alliance up and to progress as soon as possible towards the clinical testing of effective and safe drugs considering that our disease needs a chronic treatment. This goal seems to be nearing completion with a novel generation of synthetic compounds developed by SYNTHENA in cooperation with SQY and several academic entities.

Ulysse Nardin Exo-Skeleton X (for Only Watch 2019)

As things stand, this novel compound is safe in rodents and non-human primates, and according to mouse models of the disease it allows dystrophin rescue and functional improvement in skeletal muscles, heart and brain following few weeks of treatment.

Breguet Type 20 (for Only Watch 2019)

Nonetheless, in the shorter term, we are supporting top quality medical studies on the management of the cardiac complications through the retrospective analysis of enriched databases “genotype/treatment/phenotype” to evaluate the benefit, if there is, of certain combinations of drugs prescribed to patients over the last decade, as well as we contribute on demand to ongoing clinical trials to accelerate the implementation of the best care practices.

We are conscious that there is still much to be done and that our initiative needs, more than ever, help and support.

Patek Philippe Grandmaster Chime (for Only Watch 2019)
Tags: only watch only watch 2019

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